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THE JOURNAL OF BIOLOGICAL CHEMISTRY © 1998 by The American connection for Biochemistry and molecular Biology, Inc. Vol. 273, No. 45, Issue of November 6, pp. 2987329878, 1998 Printed in U.S.A. The Mechanism underlying cystic Fibrosis Transmembrane Conductance Regulator Transport from the Endoplasmic Reticulum to the Proteasome Includes Sec61 and a Cytosolic, Deglycosylated intermediary* (Received for publication, July 9, 1998) Zsuzsa Bebok‡§, Christopher Mazzochi¶, Scott A. King¶, Jeong S. Hong , and Eric J. Sorscher‡§¶** ¨ From the Departments of ‡Medicine, kiosk Biology, and ¶Physiology and Biophysics and §Gregory Fleming James cystic Fibrosis look for Center, University of atomic number 13 at Birmingham, Birmingham, Alabama 35294 * The cost of publication of this article were defrayed in part by the compensation of page charges. This article must(prenominal) therefore be herewith marked advertisement in accordance with 18 U.S.C. Secti on 1734 merely to indicate this fact. ** To whom concord should be addressed: Depts. of Medicine and Physiology and Biophysics, Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, 1918 University Blvd., Rm. 798 BHSB, Birmingham, AL 35294. Tel.: 205-934-9640; Fax: 205-934-7593; email: sorscher@phybio.bhs.uab.edu.

This radical is available on line at hypertext transfer protocol://www.jbc.org The cystic fibrosis transmembrane conductance regulator (CFTR)1 was among the first membrane proteins for which the role of the proteasome in ER-associated proteolysis was describe (1, 2). CFTR is an integral multidomain membrane protein localized t o the apical go up of epithelial cells that! functions to urge Cl transport (3). Certain mutations in the CFTR gene, including the frequent F508 mutation, lead to quick degradation of the protein prior to ichor beyond the endoplasmic reticulum (4). Wild-type CFTR sheepfold and processing is inefficient (5). In vitro, up to 75% of fresh synthesized wild-type...If you want to get a full essay, order it on our website: OrderEssay.net

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